Method for producing liposome and method for dissolving...

B - Operations – Transporting – 01 – J

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B01J 13/04 (2006.01) A61K 8/14 (2006.01) A61K 8/55 (2006.01) A61K 8/63 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2735968

Disclosed is a method for producing a liposome, which comprises: a first mixing step wherein one or more lipids are mixed with an aqueous solution containing a water-miscible organic solvent; a heating step wherein the mixture obtained by mixing the lipids with the aqueous solution is heated to a temperature at which the lipids are dissolved in the aqueous solution; and a cooling step following the heating step, wherein the resulting mixture is cooled down to a temperature at which a liposome is produced. Uniform-sized liposomes having a high encapsulation rate can be easily obtained by the method.

L'invention concerne un procédé de fabrication d'un liposome, qui comprend : une première étape de mélange lors de laquelle un ou plusieurs lipides sont mélangés avec une solution aqueuse contenant un solvant organique miscible avec l'eau ; une étape de chauffage lors de laquelle le mélange obtenu par mélange des lipides avec la solution aqueuse est porté à une température à laquelle les lipides sont dissous dans la solution aqueuse ; et une étape de refroidissement qui suit l'étape de chauffage et lors de laquelle le mélange résultant est refroidi à une température à laquelle un liposome est produit. Des liposomes de taille uniforme ayant un taux d'encapsulation élevé peuvent facilement être obtenus par le procédé.

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