Method for producing nebivolol

Details Method for producing nebivolol Method for producing nebivolol

C - Chemistry, Metallurgy

07

D

C07D 311/58 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2615832

The invention relates to a method for producing the racemic active ingredient Nebivolol, preferably in the form of the hydrochloride of formula (1), according to which diastereomer cyanhydrins of general formula (2) are produced and separated, and the separated diastereomers are coupled together following a transformation, preferably a partial or full reduction of the cyano group or a Pinner saponification.

L'invention concerne un procédé permettant de produire le principe actif racémique Nébivolol, selon lequel des cyanhydrines diastéréomères sont produites, séparées et les diastéréomères séparés sont à nouveau accouplés, après une transformation, de préférence une réduction partielle ou complète du groupe cyano ou une saponification de Pinner.

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