C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/9, 260/90
C07J 9/00 (2006.01) C07J 13/00 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01) C07J 51/00 (2006.01)
Patent
CA 1079267
ABSTRACT OF THE DISCLOSURE A process is provided for producing a new series of fusidic acid derivatives, and salts and easily hydrolysable esters thereof. The new fusidic acid derivatives have the general formula Image I in which Q1 and Q2 stand for the group Image or oxygen, A represents oxygen or sulphur, and R1 stands for a substituted or unsubstituted straight or branched alkyl radical having from 1 to 12 carbon atoms, or a substituted or unsubstituted alkenyl or alkynyl radical having from 3 to 6 carbon atoms, or an unsubstituted or substituted cycloalkyl radical having from 3 to 7 carbon atoms in the alicyclic ring, or an unsubstituted or substituted aralkyl or aryl radical, or a heterocyclic radical having 5 or 6 ring atoms and containing oxygen, sulphur and/or nitrogen atoms. In formula I the dotted line between C-24 and C-25 indicates that the carbon atoms in question are connected by either a double bond or a single bond, and the asterix at C-20 indicates that the compounds exist in two diastereomeric forms. Pure diastereomers , well as mixtures of these are prepared according to the inverted process. Such compounds possess antibacterial properties and show further interesting antimicrobial and pharmacokinetic properties.
266994
Daehne Welf von
Rasmussen Poul R.
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