C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 11/00 (2006.01) A61K 31/7016 (2006.01) A61K 31/7024 (2006.01) A61K 31/7028 (2006.01) A61K 38/04 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) C07H 5/06 (2006.01) C07H 15/04 (2006.01) C07J 41/00 (2006.01) C07K 5/04 (2006.01)
Patent
CA 2293964
A method for producing oligosaccharides, including those usable as anti-inflammatory agent or anti-allergy agent, represented by the following general formula (3): (see formula I) wherein R10 and R11 each independently represent a hydrogen atom or -SO3M where M represents a proton or a monovalent cation, Ac represents an acetyl group, R12 represents a hydrogen atom or an anomeric substituent (a 6-O-sulfated N-acetylglucosamine residue, an alkyl group, a glycerol residue, an O-alkylglycerol residue, a cholesterol residue, a cholestanyl group, a ceramide residue, a phospholipid residue, a biotin residue, or a peptide residue), and Z represents an oxygen atom or -NHCO-, which method comprises at least a step of carrying out glycosidic linkage formation between a monosaccharide represented by the following general formula (1): (see formula II) wherein R1 and R2 each independently represent an aralkyl group, R3 represents an acyl group or a silyl group, R4 represents a protective group for an amino group, and R5 represents a leaving group, and a monosaccharide represented by the following general formula (2): (see formula III) wherein R6 and R8 each independently represent an aralkyl group, R7 represents an acyl group or a silyl group, R9 represents an aralkyl group or the anomeric substituent, and Z is as defined above.
Hori Yusuke
Iida Masami
Matsuzaki Yuji
Miyauchi Satoshi
Mochizuki Hideo
Seikagaku Corporation
Smart & Biggar
LandOfFree
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