Method for producing optically active, cyclic depsipeptides...

Details Method for producing optically active, cyclic depsipeptides... Method for producing optically active, cyclic depsipeptides...

C - Chemistry, Metallurgy

12

P

C12P 17/14 (2006.01)

Patent

CA 2746733

The present invention relates to a process for the preparation of lactic- and phenyllactic-acid-containing, optically active, cyclic depsipeptides with 24 ring atoms by means of fungal strains of the genus Rosellinia and further Xylariaceae isolated not only from fruiting bodies of Rosellinia spp. and Xylariaceae growing on dead timber and live timber of deciduous and coniferous trees, but also directly from timber and roots of deciduous, and coniferous trees, or by means of enzymatic preparations isolated from these fungal strains. PF1022A, of the general formula (I), is outstandingly suitable for controlling endoparasites, in particular in the field of medicine and veterinary medicine.

La présente invention porte sur un procédé de fabrication de depsipeptides cycliques contenant de l'acide lactique et de l'acide phényllactique, optiquement actifs, avec 24 atomes de cycle au moyen non seulement des représentants des espèces Rosellinia et Coniolariella (Xylariaceae) issus de corps de fruits se développant sur du bois mort et du bois vivant d'arbres feuillus et résineux, mais encore des souches de champignon du genre Rosellinia isolées directement à partir de bois et de racines d'arbres feuillus et résineux ainsi que d'autres Xylariaceae ou au moyen de préparations enzymatiques isolées à partir de ces souches de champignon. PF1022A avec la formule générale (I) se prête de manière excellente à la lutte contre les endoparasites, en particulier dans le domaine de la médecine humaine et vétérinaire.

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