Method for producing –-(p-isobutylphenyl)-propionic acid or...

C - Chemistry – Metallurgy – 07 – C

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C07C 47/228 (2006.01) C07C 4/00 (2006.01) C07C 45/50 (2006.01) C07C 51/14 (2006.01) C07C 51/29 (2006.01) C07C 57/30 (2006.01) C07C 69/612 (2006.01)

Patent

CA 1314051

ABSTRACT OF THE DISCLOSURE A method for producing .alpha.-(p-isobutylphenyl)- propionic acid or its alkyl esters which is characterized in that starting materials are inexpensive, processes are easy to be done and products are highly pure. The method comprises the steps of (I): catalytically cracking 1,1-bis(p-isobutylphenyl)ethane at temperatures in the range of 200 to 650°C in the presence of a protonic acid catalyst and/or a solid acid catalyst to produce isobutylbenzene and p-isobutylstyrene; and (II): reacting said p-isobutylstyrene with carbon monoxide and water or alcohol at temperatures in the range of 40 to 150°C in the presence of a metal complex carbonylation catalyst to produce .alpha.-(p-isobutylphenyl)- propionic acid or its alkyl ester; or (III): reacting said p-isobutylstyrene with carbon monoxide and hydrogen at temperatures in the range of 40 to 150°C in the presence of a metal complex carbonylation catalyst to produce .alpha.-(p-isobutylphenyl)propionaldehyde and then oxidizing said .alpha.-(p-isobutylphenyl)propionaldehyde to produce .alpha.-(p-isobutylphenyl)propionic acid. The recovered isobutylene is recycled to produce 1,1-bis(p-isobutyl- phenyl)ethane by reaction with acetaldehyde in the presence of sulfuric acid.

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