Method for producing pentacyclic taxans

Details Method for producing pentacyclic taxans Method for producing pentacyclic taxans

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/443 (2006.01) A61P 35/00 (2006.01) C07D 213/61 (2006.01)

Patent

CA 2565013

A taxane derivative useful as an antitumor compound capable of oral administration is highly efficiently produced at low cost. An alkali metal permanganate is caused to act on a compound represented by the formula (1) (wherein R1 means alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or a heterocyclic group and R2 means optionally protected hydroxy) to produce a compound represented by the formula (2), which is a raw material for an antitumor compound capable of oral administration. [Chemical formula 1]

Un dérivé de taxane utile comme composé antitumoral et pouvant être administré oralement, il est produit très efficacement à faible coût. Un permanganate de métal d'alcali est amené à agir sur un composé représenté par la formule (1) (où R<1> désigne de l'alkyle, de l'alkényle, de l'alkynyle, du cycloalkyle, de l'aryle ou un groupe hétérocyclique et R<2> désigne de l'hydroxy optionnellement protégé) pour produire un composé représenté par la formule (2), qui est une matière première pour un composé antitumoral pouvant être administré par voie orale. [Formule chimique 1] (1) -> (2)

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