C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61P 7/04 (2006.01) C12M 3/00 (2006.01)
Patent
CA 2745268
The present invention relates to a method for producing platelets from mature megakaryocytes. More particularly, the invention relates to an ex vivo method for producing platelets, from mature megakaryocytes, said method comprising a step of subjecting a suspension of mature megakaryocytes to a flow having a minimal shear rate of 600 s-1 on a solid phase coated with Von Willebrand factor.
La présente invention concerne un procédé pour produire des plaquettes à partir de mégacaryocytes matures. Plus particulièrement, linvention concerne un procédé ex vivo pour produire des plaquettes, à partir de mégacaryocytes matures, ledit procédé comprenant une étape consistant à soumettre une suspension de mégacaryocytes matures à un flux ayant un taux de cisaillement minimal de 600 s-1 sur une phase solide revêtue avec du facteur de Von Willebrand.
Baruch Dominique
Cramer-Borde Elisabeth
Dunois-Larde Claire
Assistance Publique - Hopitaux de Paris
Inserm (institut National de La Sante Et de La Recherche Medical
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universite de Versailles Saint-Quentin-En-Yvelines
Universite Paris Descartes
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