C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 81/00 (2006.01) A61K 31/282 (2006.01) A61P 35/00 (2006.01) C07F 15/00 (2006.01)
Patent
CA 2611450
Disclosed is a process for production of a polymerized coordination compound comprising reacting bis(nitrolat) platinum complex with a poly(ethylene glycol)-block-poly(glutamic acid) at a specific ratio optionally in the presence of a dihalo platimum complex. The process can produce a coordination compound of a block copolymer which has an anti-tumor platinum complex and a carboxyl group on a side chain with good efficiency.
L'invention concerne un procédé de fabrication d'un composé polymère coordonné, comprenant la réaction d'un complexe de platine bis(nitrolat) avec un poly(éthylène glycol)-bloc-poly(acide glutamique) dans un rapport spécifique, éventuellement en présence d'un complexe de platine dihalo. Le procédé permet d'obtenir efficacement un composé coordonné d'un copolymère séquencé, comportant un complexe de platine présentant une action antitumorale, et un groupe carboxyle sur une chaîne latérale.
Kataoka Kazunori
Kobayashi Katsutoshi
Nagasaki Shoko
Tsuchiya Chieko
Nanocarrier Co. Ltd.
Smart & Biggar
The University Of Tokyo
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