Method for producing polypeptide via bacterial fermentation

Details Method for producing polypeptide via bacterial fermentation Method for producing polypeptide via bacterial fermentation

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) B01F 3/04 (2006.01) B01F 15/00 (2006.01) C07K 14/65 (2006.01) C12M 1/06 (2006.01) C12M 1/36 (2006.01) C12M 3/02 (2006.01) C12N 9/02 (2006.01) C12N 15/01 (2006.01) C12P 21/02 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2147468

A process for producing a polypeptide of interest from fermentation of bacterial host cells comprising nucleic acid encoding the polypeptide is provided. In this method, the host cells employed have an inactivated election transport chain. Further provided is a method for determining if a particular bacterial cell culture has a propensity for dissolved oxygen instability when fermented on a large scale.

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