Method for producing protein microspheres

Details Method for producing protein microspheres Method for producing protein microspheres

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 49/00 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2071840

Protein microspheres are formed by phase separation in a non-solvent followed by solvent removal. The preferred proteins are prolamines, such as zein, that are hydrophobic, biodegradable, and can be modified proteolytically or chemically to endow them with desirable properties, such as a selected degradation rate. Composite microspheres can be prepared from a mixture of proteins or a mixture of proteins with one or more bioerodible polymeric materials, such as polylactides. Protein coatings can al- so be made. Compounds are readillly incorporated into the microspheres for subsequent release. The process does not involve agents which degrade most labile proteins. The microspheres have a range of sizes and multiple applications, including drug de- livery and delayed release of pesticides, fertilizers, and agents for environmental cleanup. Selection of microspheres size in the range of less than five microns and mode of administration can be used to target the microparticles to the cells of the reticuloend- othelial system, or to the mucosal membranes of the mouth or gastrointestinal tract. Larger implants formed from the micros- pheres can also be utilized, especially for agricultural applications.

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