Method for producing quinolone carboxylic acid derivative

Details Method for producing quinolone carboxylic acid derivative Method for producing quinolone carboxylic acid derivative

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) C07D 215/56 (2006.01) C07D 498/06 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2679852

Disclosed is a method for producing a quinolone compound having high antibacterial activity and safety by a simple process with high yield. Specifically, a desired quinolone carboxylic acid derivative (1) shown below is produced in one pot by reacting a compound (2) shown below, a salt of a cyclic amine (3) shown below and a boron derivative in a solvent in the presence of a base. (2) (3)(1)

L'invention concerne un procédé de production d'un composé de quinolone ayant une activité antibactérienne et une tolérance élevée par un procédé simple en un rendement important. Spécifiquement, un dérivé d'acide quinolone-carboxylique souhaité (1) présenté ci-dessous est produit dans un récipient en faisant réagir un composé (2) présenté ci-dessous, un sel d'amine cyclique (3) présenté ci-dessous et un dérivé de bore dans un solvant en présence d'une base. (2) (3) (1)

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