Method for producing recombinant proteins in micro-organisms

Details Method for producing recombinant proteins in micro-organisms Method for producing recombinant proteins in micro-organisms

C - Chemistry, Metallurgy

12

N

C12N 9/68 (2006.01) A61K 38/48 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) C12N 1/19 (2006.01) C12N 15/57 (2006.01) C12N 15/62 (2006.01) C12N 15/81 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2475277

The invention relates to a method for producing a recombinant functional plasminogen in micro-organisms, and to a method for identifying plasminogen activators. The nucleic acid sequence coding for the functional part of the plasminogen is fused with a nucleic acid molecule coding for at least one signal peptide. The nucleic acid molecule coding for the plasminogen and the nucleic acid molecule coding for the signal peptide are combined with codons for interfaces of proteases which ensure the separation of the signal peptide. The recombinant plasminogen or the corresponding plasmine is suitable for treating wounds which are slow to heal or not healing, by application of the enzyme in an appropriate formulation.

La présente invention concerne un procédé pour produire un plasminogène de recombinaison fonctionnel dans des micro-organismes et un procédé pour identifier des activateurs de plasminogène. La séquence d'acides nucléiques codant la partie fonctionnelle du plasminogène est fusionnée avec une molécule d'acide nucléique qui code au moins un peptide signal. La molécule d'acide nucléique codant le plasminogène et la molécule d'acide nucléique codant le peptide signal sont combinées avec des codons d'interface de protéases qui assurent le détachement du peptide signal. Le plasminogène de recombinaison et la plasmine correspondante sont utilisés pour traiter des plaies qui guérissent lentement ou qui ne guérissent pas, par application de l'enzyme se trouvant dans une formulation adéquate.

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