Method for producing s-alkyl(aryl)-substituted imidazol...

Details Method for producing s-alkyl(aryl)-substituted imidazol... Method for producing s-alkyl(aryl)-substituted imidazol...

C - Chemistry, Metallurgy

07

D

C07D 233/90 (2006.01)

Patent

CA 2319138

The invention relates to a process for the preparation of compounds of the formula (I) (see formula I) in which R(2) and R(3) independently of one another are - SR(4) or - COOR(5) and R(1), R(4) and R(5) have the meaning indicated in the description, which comprises cyclizing compounds of the formula II (see formula II) in which R(1), R(2) and R(3) have the meaning defined above, in the presence of alkylphosphonic anhydrides to give compounds of the formula (I), then purifying these in as is known per se by salt formation and, if appropriate, subsequent recrystallization and optionally removing radicals introduced for the protection of other functional groups in a manner known per se; and their use as intermediate for the synthesis of active compounds.

L'invention concerne un procédé de fabrication de composés de formule (I), dans laquelle R(2) et R(3) désignent, indépendamment l'un de l'autre, -SR(4) ou -COOR(5), et R(1), R(4) et R(5) ont les significations données dans la description, caractérisé en ce qu'on cyclise des composés de formule (II), dans laquelle R(1), R(2) et R(3) ont les significations précitées, en présence d'anhydrides d'acide alkylphosphonique, en composés de formule (I), en ce qu'on purifie ensuite ces produits, de façon connue en soi, par salification suivie éventuellement d'une recristallisation, et en ce qu'on sépare éventuellement, de façon connue en soi, les restes introduits pour la protection d'autres groupes fonctionnels. L'invention concerne en outre l'utilisation de ces composés comme produits intermédiaires pour la synthèse de substances actives.

Affiliated with

Also associated with

Rating

Method for producing s-alkyl(aryl)-substituted imidazol... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing s-alkyl(aryl)-substituted imidazol..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing s-alkyl(aryl)-substituted imidazol... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1778571