Method for producing salts of cyclic amidines

Details Method for producing salts of cyclic amidines Method for producing salts of cyclic amidines

C - Chemistry, Metallurgy

07

D

C07D 207/22 (2006.01) C07B 43/00 (2006.01) C07D 211/68 (2006.01)

Patent

CA 2313194

The invention relates to a method for producing salts of cyclic amidines of general formula (I). Known methods for producing salts of compound (I) only produce low yields. According to the invention, the appropriate .omega.-amino- .alpha.-amino acids are selectively protected in the .omega.-amino function. These protected compounds are decarboxylated oxidatively using halogen derivatives and the oxidatively decarboxylated substances are then cyclised with acid being added. This results in better yields of the salts of compound (I).

L'invention concerne un procédé pour la production de sels d'amidines cycliques de formule générale (I). Les procédés connus ne permettant une production des sels du composé (I) qu'à faibles rendements, l'invention vise à améliorer les rendements en sels du composé (I). A cet effet, on procède à une protection sélective d'acides .omega.-amino .alpha.-amino correspondants au niveau de la fonction .omega.-amino et à une décarboxylation oxydative de ces composés protégés au moyen de dérivés halogénés, puis on cyclise les substances oxido-décarboxylées en ajoutant de l'acide.

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