Method for producing salts of tolperisone

Details Method for producing salts of tolperisone Method for producing salts of tolperisone

C - Chemistry, Metallurgy

07

D

C07D 295/10 (2006.01) C07D 295/108 (2006.01)

Patent

CA 2507691

The invention relates to a method for producing an acid addition salt of 2,4'- dimethyl-3- piperidino-propiophenone (tolperisone) with a pharmaceutically acceptable acid, of the formula (I). (see formula I) According to the invention, 4-methylpropiophenone is reacted with piperidine hydrochloride and 1,2-dioxolane in the presence of an acid serving as a catalyst, and the tolperisone obtained in the form of an acid addition salt is separated by filtering after the reaction mixture has cooled down.

L'invention concerne un procédé de production d'un sel d'addition de 2,4'-diméthyl-3-pipéridinopropiophénone (tolpérisone) au moyen d'un acide pharmaceutiquement acceptable de formule (B). Ce procédé consiste : à faire réagir de la 4-méthylpropiophénone avec de l'hydrochlorure de pipéridine et du 1,2-dioxolane, en présence d'un acide en tant que catalyseur ; et à séparer la tolpérisone produite sous forme de sel d'addition acide, par filtration du mélange réactionnel une fois refroidi.

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