Method for producing sorbicillactone a

Details Method for producing sorbicillactone a Method for producing sorbicillactone a

C - Chemistry, Metallurgy

12

N

C12N 1/38 (2006.01) A61K 31/343 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C12P 17/04 (2006.01)

Patent

CA 2554733

The invention relates to an improved method for cultivating the fungus Penicillium chrysogenum, especially strain KIP 3201, for producing the antitumoral natural substance Sorbicillactone A of formula (I) and its derivatives in an optimized manner and in large amounts. The invention also relates to an optimized method for obtaining and purifying said substance from the fungal biomass and from the culture medium. The invention also describes the biological activity of Sorbicillactone A of formula (I) and investigations relating to the genotoxicity of the compound.

L'invention concerne un procédé pour améliorer la culture de champignons Penicillium chrysogenum, en particulier la souche KIP 3201, ce qui permet une production optimisée du produit naturel antitumoral, le sorbicillactone A (2), et ses dérivés en grande quantité. L'invention concerne également des procédés améliorés pour extraire et pour purifier lesdits champignons hors de la biomasse des champignons et de leur milieu de culture. L'invention concerne, en outre, l'activité biologique du sorbicillactone A (2) et l'analyse de la génotoxicité du composé.

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