A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/60 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 47/00 (2006.01) A61K 47/08 (2006.01) A61K 47/10 (2006.01) A61K 47/22 (2006.01) A61K 47/26 (2006.01)
Patent
CA 2298464
The invention relates to a method for producing stable acetylsalicylic acid solutions with non-aqueous pharmaceutically acceptable organic solvents such as dimethylisosorbide, propylene glycol or diethylene glycol monoethyl ether, wherein 0.005 - 2 wt. % of a cyclic acidic imide and/or 0.005 - 2 wt. % of a sulphamic acid and preferably 1 - 40 wt. %, in relation to the weight of the solution, of a compound of general formula (I) is added to the solution. In said general formula, R1 stands for H, CH3 or C2H5, n = 0 or 1 and R2 is H or one or more low alkyl, low alkyloxy or low alkenyl radicals with 1 to 5 C atoms.
L'invention concerne un procédé pour préparer des solutions stables d'acide acétylsalicylique, au moyen de solvants organiques non aqueux pharmaceutiquement acceptables, tels que diméthylisosorbitol, propylèneglycol ou monoéthyléther de diéthylèneglycol. Selon ce procédé, on ajoute à la solution 0,005 % à 2 % en poids d'un imide d'acide cyclique et/ou 0,005 à 2 % en poids d'un acide sulfaminique ainsi que de préférence 1 à 40 % en poids, par rapport à la solution, d'un composé de formule générale (I). Dans ladite formule, R¿1? représente H, CH¿3? ou C¿2?H¿5?, n vaut 0 ou 1, et R¿2? représente H ou un reste alkyle inférieur, alkyloxy inférieur ou alcényl inférieur comportant 1 à 5 atomes de C.
Burghart Kurt
Burghart Walter
Burghart Kurt
Burghart Walter
Ridout & Maybee Llp
LandOfFree
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