Method for producing sustained release formulation

Details Method for producing sustained release formulation Method for producing sustained release formulation

A - Human Necessities

61

K

167/170

A61K 9/22 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 1277601

Abstract: The present invention is directed to a method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps of: (i) preparing a uniform and highly concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture of water and a hydrophilic organic solvent under one of the conditions selected from: (A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration; (B) chemically modified collagen and/or gelatin is employed; and (C) glucose is added to the mixture; (ii) molding the resultant mixture; and (iii) gradually eliminating the solvent from the molded product.

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