Method for producing transdermal patches

Details Method for producing transdermal patches Method for producing transdermal patches

A - Human Necessities

61

M

A61M 35/00 (2006.01) A61F 13/02 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2240416

The invention relates to a method for continuous production of transdermal patches. In said method, a laminate comprising an auxiliary layer (3) which is siliconised on one side, a self-adhesive layer (4) containing the active ingredient, and a carrier layer (9) is provided in the form of a striplike band (1). The sections (4') containing the active ingredient and obtained by punching out the layers (3) and (4) at right angles to the direction of the band are transferred in stages to a second band (2). There is punching out during the resting stage between the stages and transfer to the second band (2) is carried out at preferably equal distances using transfer means (11, 12). The invention is characterised in that during transfer the carrier layer (9) is initially removed from the sections (4') containing the active ingredient and subsequently the sections (3') of the auxiliary layer are removed using a self-adhesive process layer (5).

L'invention concerne un procédé de production continue de systèmes thérapeutiques transdermiques, selon lequel un stratifié, comprenant une couche auxiliaire (3) siliconée au moins d'un côté, une couche (4) adhésive sensible à la pression contenant le principe actif et une couche support (9), se présente sous forme de bande striée (1). Les sections (4') qui contiennent le principe actif sont obtenues par poinçonnage des couches (3) et (4), transversalement au sens de la bande, et sont transférées par cycles sur une seconde bande (2). Le poinçonnage intervient pendant la période de repos entre les cycles et le transfert sur la seconde bande (2) s'effectue à l'aide d'un dispositif de transfert (11, 12), de préférence avec des espacements réguliers. Ce procédé se caractérise en ce que, lors du transfert, la couche support (9) est d'abord enlevée des sections (4') contenant le principe actif, puis les sections (3') de la couche auxiliaire sont enlevées à l'aide d'une couche (5) utilisée pour ce procédé qui est pourvue d'un adhésif sensible à la pression.

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