A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01)
Patent
CA 2623112
The invention concerns a method for producing ultrafine suspensions, characterized in that a substance in the form of a solid product at 20 ~C is dissolved in a solvent, in that the solvent is very rapidly substantially drawn from said solution, in that the powder thus obtained, whereof the particles have an average particle-size distribution of the order of 1 to 50 µm (by laser diffractometry) is dispersed in a dispersing medium, and in that the resulting suspension is treated subsequently, using average to high forces, so as to obtain a suspension whereof the solid matter particles have a average particle-size distribution (by photon correlation spectroscopy) less than 3 µm, preferably less than 1µm (1000 nm), and in particular less than 400 nm, more particularly still, less than 200 nm.
L'invention concerne un procédé de production de suspensions ultrafines, caractérisé en ce qu'une substance se présentant, à 20 °C, sous forme d'un produit solide, est mise en solution dans un solvant, en ce que le solvant est, très rapidement, sensiblement soutiré de cette solution, en ce que la poudre ainsi obtenue, dont les particules présentent une granulométrie moyenne de l'ordre de 1 à 50 µm (par diffractométrie au laser) est dispersée dans un milieu dispersant, et en ce que la suspension ainsi obtenue est traitée ultérieurement, en utilisant des forces moyennes à élevées, de manière à obtenir une suspension dont les particules de matière solide présentent une granulométrie moyenne (par spectroscopie de corrélation de photons, PCS) inférieure à 3 µm, de préférence inférieure à 1 µm (1000 nm), et en particulier inférieure à 400 nm, plus particulièrement, inférieure à 200 nm.
Moschwitzer Jan
Abbott Gmbh & Co. Kg.
Blake Cassels & Graydon Llp
LandOfFree
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