C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/103, 260/108
C07D 501/16 (2006.01) C07F 9/6571 (2006.01) C07F 9/6574 (2006.01)
Patent
CA 1219856
ABSTRACT A novel method of producing a cephalosporin compound of the formula Image [I] wherein R1 is a hydrogen atom or an acyl group; R is a hydrogen atom or an ester residue; the dotted line means a double bond in 2- or 3-position of the cephem ring; and R4 is a nucleophilic compound residue, or a salt thereof, directly in one step from a compound of the formula Image [II] wherein R1, R and the dotted line have the meanings defined above, or a salt thereof, by reacting in the presence of an organic solvent the compound [II] or a salt thereof, a nucleophilic compound or a salt thereof, and (1) a trivalent or cyclic phosphorus compound having a partial structure of the formula Image wherein W is an oxygen atom, a sulfur atom or NR2; W1 is an oxygen atom, a sulfur atom or NR3; and R2 and R3 may be the same or different and each means a hydrogen atom or a hydrocarbon group, or a salt thereof, or (2) a reaction product of a compound having a partial structure of the formula Image wherein W and W1 have the same meanings as defined above, or a salt thereof, with a phosphorus oxyhalide, trihalide or Cephalosporin compounds [I] provide valuable antimicrobial compounds and are also important intermediate compounds for the production of such cephalosporin compounds.
411185
Kato Masayasu
Naito Kenzo
Tsukamura Kazuo
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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