Method for production of l-cysteine or l-cysteine...

C - Chemistry – Metallurgy – 12 – N

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C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12N 15/67 (2006.01) C12N 15/70 (2006.01) C12P 13/12 (2006.01)

Patent

CA 2386539

The invention relates to a method for production of l-cysteine or l-cysteine derivatives by means of a fermentation with micro-organisms and micro-organisms suitable for said method. The micro- organism strain adapted to fermentative production of l-cysteine or l-cysteine derivatives comprises a deregulated cysteine metabolism which is not dependent upon an altered cysB activity. Said micro-organism strain is furthermore characterized by an elevated cysB activity, whereby the cysB activity comprises a regulation pattern typical for a wild type cysB.

L'invention concerne des procédés pour produire de la L-cystéine ou des dérivés de cette dernière par fermentation de micro-organismes, ainsi que des micro-organismes adaptés audit procédé. La souche de micro-organismes adaptée à la production de L-cystéine ou de dérivés de cette dernière par fermentation possède un métabolisme de la cystéine déréglé qui n'est pas dû à une modification de l'activité de la CysB. Cette souche est caractérisée en ce qu'elle possède en outre une activité accrue de la CysB, qui présente un modèle de régulation caractéristique de la CysB de type sauvage.

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