Method for production of microcapsules

Details Method for production of microcapsules Method for production of microcapsules

B - Operations, Transporting

01

J

B01J 13/06 (2006.01)

Patent

CA 2371200

The invention provides a process for microencapsulating a pharmaceutical substrate comprising the steps of: a) adding insoluble or sparingly soluble particles of the substrate to be microencapsulated to a stable buffer solution having a high ionic strength; b) dissolving a membrane-forming ionic polymer in the buffer; c) forming a coacervate by adding a water-complexing compound causing phase separation of the resulting mixture; and d) allowing the deposition of the coacervate onto the substrate so as to create a coating of polymer around the substrate.

L'invention concerne un procédé de microencapsulation d'un substrat pharmaceutique. Ce procédé comprend les étapes suivantes : a) on ajoute des particules insolubles ou faiblement solubles du substrat à encapsuler à une solution tampon stable à force ionique élevée, b) on dissout un polymère ionique filmogène dans la solution tampon, c) on prépare un coacervat en ajoutant un composé formant un complexe avec l'eau et provoquant une séparation de phases dans le mélange résultant, d) on laisse le coacervat se déposer sur le substrat de manière à former un revêtement de polymère autour du substrat.

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