Method for production of reprogrammed cell using...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/09 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2731007

An objective of the present invention is to provide vectors for conveniently and efficiently producing ES-like cells in which foreign genes are not integrated into the chromosome. The present inventors discovered methods for producing ES-like cells from somatic cells using chromosomally non-integrating viral vectors. Since no foreign gene is integrated into the chromosome of the produced ES-like cells, they are advantageous in tests and research, and immunological rejection and ethical problems can be avoided in disease treatments.

L'invention porte sur un vecteur pour la production commode et efficace d'une cellule de type ES ne comportant pas de gène étranger intégré dans son chromosome. L'invention porte également sur un procédé de production d'une cellule de type ES à partir d'une cellule somatique à l'aide d'un vecteur viral chromosomiquement non intégré. La cellule de type ES produite par le procédé ne comporte pas de gène étranger intégré dans son chromosome. Par conséquent, la cellule peut être avantageusement utilisée pour des tests et études, et offre une possibilité élevée de suppression du problème de rejet immunologique ou des problèmes éthiques dans le traitement des maladies.

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