Method for production of stable nicorandil preparation

Details Method for production of stable nicorandil preparation Method for production of stable nicorandil preparation

A - Human Necessities

61

K

167/229

A61K 31/455 (2006.01) A61K 9/02 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01)

Patent

CA 1255227

METHOD FOR PRODUCTION OF STABLE NICORANDIL PREPARATION Abstract of the Disclosure: A method for producing a stable pharmaceutical preparation containing nicorandil as an active ingredient is disclosed. The stable preparation is produced by mixing nicorandil, one or more finely comminuted sugars, and/or one or more powdery organic acids. Nicorandil which is useful as a curative for various types of angina petoris is not stable against the compres- sive pressure exerted by punching operations in tabelt making or against moisture. The preparation of nicorandil manufactured by this invnetion is very stable and useful in clinical applications.

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