Method for production of stable nicorandil preparation

Details Method for production of stable nicorandil preparation Method for production of stable nicorandil preparation

A - Human Necessities

61

K

167/229

A61K 31/455 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1285486

METHOD FOR PRODUCTION OF STABLE NICORANDIL PREPARATION Abstract of the Disclosure: A method for producing a stable preparation contain- ing nicorandil, a saturated higher aliphatic acid or a saturated higher alcohol which is solid at ordinary tempera- tures, and optionally, an organic acid such as fumaric acid, oxalic acid, salicylic acid, tartaric acid or glutaric acid is disclosed. Nicorandil is useful as a curative for various types of angina pectoris. However, it is unstable in humid condi- tions and under the compressive pressure exerted by punching operations in tablets making and, therefore, the development of a stable nicorandil preparation has been desired.

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