A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2223412
The invention provides a method for enhancing the expression of a gene of interest by a cell, the cell (a) comprises a recombinant nucleic acid sequence encoding and (b) is capable of expressing the gene of interest, the method comprising contacting the cell with an amount of a soluble CTLA4 molecule effective to enhance the expression of the gene of interest by the cell.
L'invention se rapporte à un procédé visant à améliorer l'expression d'un gène d'intérêt par une cellule, cette cellule (a) comprenant une séquence d'acide nucléique de recombinaison codant pour et (b) capable d'exprimer le gène d'intérêt. Le procédé consiste à mettre en contact la cellule avec une quantité efficace d'une molécule CTLA4 soluble permettant d'améliorer l'expression du gène d'intérêt par la cellule.
Aruffo Alejandro A.
Hollenbaugh Diane L.
Kay Mark A.
Ledbetter Jeffrey
Linsley Peter S.
Bristol-Myers Squibb Company
Mcmillan Llp
The University Of Washington
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