A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/337 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2697737
A method for promoting expression of p53 mRNA and an expression promoting agent for use in the method are provided. The expression of the p53 gene can be promoted by inhibiting the binding between RNA transcribed from exon 1 of the vegf-A gene and mRNA transcribed from the p53 gene. The inhibition of the binding can be achieved by, for example, degrading the RNA transcribed from the exon 1 of the vegf-A gene, inhibiting transcription of RNA from the exon 1 of the vegf-A gene, or binding a nucleic acid that is different from the mRNA transcribed from the p53 gene to the RNA transcribed from the exon 1 of the vegf-A gene.
L'invention concerne un procédé permettant de favoriser l'expression de p53 mARN. L'invention concerne également un promoteur d'expression à utiliser dans ce procédé. L'expression du gène p53 peut être favorisée par inhibition de la liaison entre ARN transcrit de exon-1 dans le gène vegf-A et mARN transcrit du gène p53. L'inhibition de la liaison peut être réalisée par, par exemple, dégradation de l'ARN transcrit de exon-1 en gène vegf-A, inhibant la transcription de ARN d'exon-1 dans le gène vegf-A, ou liant ARN transcrit d'exon-1 dans le gène vegf-A à un acide nucléique différent de mARN transcrit du gène p53.
Kondo Shigetada
Rokutan Kazuhito
Fetherstonhaugh & Co.
The University Of Tokushima
LandOfFree
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