Method for promoting hematopoietic and mesenchymal cell...

Details Method for promoting hematopoietic and mesenchymal cell... Method for promoting hematopoietic and mesenchymal cell...

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) C12N 5/077 (2010.01) A61K 35/14 (2006.01) A61K 38/08 (2006.01) C07K 7/14 (2006.01)

Patent

CA 2310852

The present invention fulfills a need in the art for methods that promote hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments and analogues thereof and AII AT2 type 2 receptor agonists.

La présente invention répond à un besoin, dans l'état actuel de la technique, de procédés favorisant la prolifération et la différentiation de cellules souches hématopoïétiques et mésenchymateuses, ou de cellules spécifiques à une lignée, par une croissance en présence d'angiotensinogène, d'angiotensine I (AI), d'analogues d'angiotensine I, de fragments d'angiotensine et de leurs analogues, d'angiotensine II (AII), d'analogues d'angiotensine II, de fragments d'angiotensine II et de leurs analogues, et d'agonistes des récepteurs AT¿2? de type 2 de l'angiotensine II.

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