A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/10 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/435 (2006.01) A61K 31/4409 (2006.01) A61K 41/00 (2006.01)
Patent
CA 2439288
Pre-treatment with .alpha., .beta. unsaturated aryl sulfones protects normal cells from the toxic side effects of ionizing radiation. Administration of a radioprotective .alpha., .beta. unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces the cytotoxic side effects of the radiation on normal cells. The radioprotective effect of the .alpha., .beta. unsaturated aryl sulfone allows the clinician to safely increase the dosage of anticancer radiation. In some instances, amelioration of toxicity following inadvertent radiation exposure may be mitigated with administration of .alpha., .beta. unsatured arylsulfone.
Selon l'invention, le prétraitement avec des arylsulfones .alpha.,.beta. insaturés protège les cellules des effets toxiques du rayonnement ionisant. En effet, l'administration d'un composé d'arysulfone .alpha.,.beta. insaturé radioprotecteur à un patient avant la radiothérapie anticancéreuse réduit les effets secondaires cytotoxiques du rayonnement sur les cellules normales. Par conséquent, l'effet radioprotecteur de l'arylsulfone .alpha.,.beta. insaturé permet au praticien d'augmenter en toute sécurité la dose de rayonnement anticancéreux. Dans certains cas, on peut atténuer la toxicité due à l'exposition accidentelle au rayonnement par l'administration d'arylsulfones .alpha.,.beta. insaturés.
Cosenza Stephen C.
Helson Lawrence
Reddy Premkumar E.
Reddy Ramana M.v.
Mccarthy Tetrault Llp
Onconova Therapeutics Inc.
Temple University Of The Commonwealth System Of Higher Education
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