Method for protecting normal cells from cytotoxicity of...

C - Chemistry – Metallurgy – 07 – C

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C07C 317/04 (2006.01) A61K 31/12 (2006.01) A61K 31/192 (2006.01) A61K 45/06 (2006.01) A61P 39/00 (2006.01) A61K 31/337 (2006.01) A61K 31/475 (2006.01)

Patent

CA 2387539

Pre-treatment with .alpha.,.beta. unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the .alpha.,.beta. unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

Un traitement préalable au moyen de sulfones d'aryle .alpha.,.beta. insaturés protège des cellules normales contre les effets secondaires cytotoxiques de deux catégories d'agents chimiothérapeutiques anticancer. L'administration d'un composé de sulfones cytoprotecteurs à un patient préalablement à une chimiothérapie anticancer par un inhibiteur de cycle cellulaire en phase mitotique ou un inhibiteur de topoisomérase permet de limiter ou d'éliminer les effets secondaires cytotoxiques exercés par un agent anticancer sur des cellules normales. L'effet cytoprotecteur du sulfone d'aryle .alpha.,.beta. insaturé permet au praticien d'augmenter sans risque le dosage de l'agent chimiothérapeutique anticancer.

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