Method for purification of ibuprofen comprising mixtures

Details Method for purification of ibuprofen comprising mixtures Method for purification of ibuprofen comprising mixtures

C - Chemistry, Metallurgy

07

C

C07C 51/43 (2006.01) C07C 57/30 (2006.01)

Patent

CA 2050709

This invention pertains to a method of purifying ibuprofen-comprising reaction product mixtures. The method of purification is based on crystallization of ibuprofen from a hydrocarbon solvent and the discovery that there are impurity complexes in the ibuprofen-comprising reaction product mixtures which cannot be removed by crystallization from a hydrocarbon solvent. The method of the invention includes at least one step in which the impurity complex in a first ibuprofen- comprising mixture is destabilized or broken up, followed by crystallization of the ibuprofen from a second solution or mixture comprising the first ibuprofen-comprising mixture, whereby the impurities which were previously complexed can than be removed from the ibuprofen by the crystallization of ibuprofen from a solvent.

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