C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/30 (2006.01) A61K 38/55 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2376986
The present invention relates to methods for purification of antithrombin-III (AT-III) by precipitation of impurities. The said methods comprise (a) adding, to a solution comprising antithrombin- III, a saccharide and citrate, in an amount sufficient for impurities to precipitate while antithrombin-III essentially remains in solution; (b) allowing impurities to precipitate; and (c) removing the precipitated impurities, thereby obtaining a solution comprising purified antithrombin-III. The invention also relates to pharmaceutical compositions, obtainable by the said methods, comprising purified antithrombin-III, as well as to reconstituted pharmaceutical compositions essentially free from visible particles.
L'invention concerne des procédés servant à purifier antithrombine-III (AT-III) par précipitation d'impuretés. Ces procédés consistent à :(a) ajouter à une solution contenant antithrombine-III, un saccharide et citrate, en quantité suffisante pour que les impuretés se précipitent, tandis qu'antithrombine-III reste dans la solution ; (b) laisser les impuretés se précipiter ; (c) enlever les impuretés précipitées, ce qui permet d'obtenir une solution contenant antithrombine-III purifiée. Elle concerne également des compositions pharmaceutiques pouvant être préparées au moyen desdits procédés et contenant antithrombine-III purifiée, ainsi que des compositions pharmaceutiques reconstituées exemptes de particules visibles.
Biovitrum Ab
Gowling Lafleur Henderson Llp
Octapharma Ag
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