Method for purifying 5'-protected 2'-deoxypurine nucleosides

Details Method for purifying 5'-protected 2'-deoxypurine nucleosides Method for purifying 5'-protected 2'-deoxypurine nucleosides

C - Chemistry, Metallurgy

07

H

C07H 1/06 (2006.01) C07H 19/16 (2006.01)

Patent

CA 2381367

A method for efficiently purifying 5' protected 2' -deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5' protected 2'-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5' protected 2'-deoxygurine nucleoside at a high purity. This invention enables synthesis of highly purified protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

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