Method for purifying an interferon

Details Method for purifying an interferon Method for purifying an interferon

C - Chemistry, Metallurgy

07

K

167/103.1, 195/1

C07K 15/26 (1990.01) A61K 37/66 (1990.01)

Patent

CA 1282022

ABSTRACT A method of purifying a polypeptide having a physiological activity such as one having interferon activities from a culture mixture of a microorganism obtained by a recombinant DNA technique and capable of producing the polypeptide is disclosed. The method comprised subjecting the cultured cells to extraction and purification in the presence of a salt of zinc or copper and poly- ethyleneimine thereby inhibiting decomposition and denaturation of the polypeptide. The extracted polypeptide can be further purified by column chromato- graphies using a column containing an anion exchange resin, column containing a cation exchange resin and column containing a gel filtration resin.

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