C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/103.1
C07K 14/57 (2006.01) C07K 1/113 (2006.01)
Patent
CA 1263842
ABSTRACT "METHOD FOR PURIFYING INTERFERON AND COMPOSITION OF MATTER PRODUCED THEREBY" A composition of matter consisting of recombinant human immune interferon having a near-UV circular dichroic spectrum in aqueous solution at neutral pH with positive bands at about 259 nm, 266 nm, 280 nm, and 287 nm, and with shoulders at about 270 nm and 292 nm. Also disclosed is a method for purifying human immune interferon in which proper refolding of the interferon is accomplished by unfolding in a denaturant, such as urea, dilution in ammonium acetate to approxi- mately 0.18 mg/ml of interferon (or less), and dialysis of the solution. The properly folded, purified product which results has a four- to eight-fold greater activity than the aggregate which otherwise results.
505897
Amgen Inc.
Arakawa Tsutomu
Ridout & Maybee Llp
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