Method for radiolabeling monovalent antibody fragments

Details Method for radiolabeling monovalent antibody fragments Method for radiolabeling monovalent antibody fragments

G - Physics

01

N

G01N 33/534 (2006.01) A61K 51/10 (2006.01) C07K 16/06 (2006.01) G01N 33/563 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082265

A method for radiolabeling a monovalent Fab or Fab' antibody fragment which comprises the steps of cleaving a divalent F(ab)2 or F(ab')2 antibody fragment using sulfite or meta-bisulfite ions to produce a monovalent fragment having a free sulf- hydryl group, and contacting the monovalent fragment with a cation of a metallic radionuclide which binds to sulfhydryl groups, without removing excess sulfite or meta-bisulfite.

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