A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 31/40 (2006.01) A61K 38/14 (2006.01)
Patent
CA 2458070
The present invention relates a method for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond in the cell wall peptide precursors of the bacteria which comprises using an antibacterial amount of vancomycin or a homolog of vancomycin and an amount of an agent effective to selectively cleave the ester bond so as to thereby re-sensitize vancomycin resistant bacteria.
L'invention concerne un procédé pour resensibiliser une bactérie gram-positive résistante à la vancomycine, dont la résistance résulte de la conversion d'une liaison amide en liaison ester dans les précurseurs peptide de la paroi cellulaire de la bactérie. Selon l'invention, on utilise une quantité antibactérienne suffisante de vancomycine ou d'un homologue de la vancomycine et une quantité suffisante d'agent pour séparer sélectivement la liaison ester, afin de resensibiliser la bactérie résistante à la vancomycine.
Boneca Ivo G.
Chiosis Gabriela
Still W. Clark
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Rockefeller University
The Trustees Of Columiba University In The City Of New York
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