Method for reacting 2-aromatic substituted 1,3-dithianes...

Details Method for reacting 2-aromatic substituted 1,3-dithianes... Method for reacting 2-aromatic substituted 1,3-dithianes...

C - Chemistry, Metallurgy

07

D

260/327.4

C07D 339/08 (2006.01) C07D 409/04 (2006.01)

Patent

CA 1114388

METHOD FOR REACTING 2-AROMATIC SUBSTITUTED 1,3-DITHIANES WITH .alpha.,.beta.-UNSATURATED KETONES TO SELECTIVELY PRODUCE 1,4- OR 1,2-ADDITION PRODUCTS AND THE PRODUCTS MADE THEREBY Abstract Method for reacting a 2-aromatic substituted 1,3-dithiane with an .alpha.,.beta.-unsaturated ketone to selectively produce either the 1,4-addition product or the 1,2-addition product and the products made thereby. The 1,2- and 1,4-addition products possess cardiovascular activity, particularly anti- hypertensive and antiarrythmic activity.

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