C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) C07K 16/06 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01)
Patent
CA 2185617
High-titer immunoglobulin preparations are produced by carrying out the following steps in succession: fractionating blood plasma from a plasma pool, whereby at least one industrially usable fraction substantially containingpolyclonal immunoglobulin G is separated, at least one residual fraction being obtained; preparing a protein solution from the protein components contained in the residual fraction obtained in the previous step or in subfractions thereof; and subjecting the resulting protein solution at least once to affinity chromatography with immobilized ligands of at least one ligand type, the specific plasma proteins being bound to the ligands, and removing the bound plasma proteins, which are converted as active components into a high-titer immunoglobulin preparation. The immunoglobulins obtained can be processed into an IV well-tolerated, storage-stable product. The method leading to a valuable immunoglobulin preparation makes use of human plasma fractions which have hitherto been rejected in conventional industrial plasma fractionation methods.
Amstutz Hanspeter
Lerch Peter G.
Morgenthaler Jean-Jacques
Fetherstonhaugh & Co.
Zlb Bioplasma Ag
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