Method for reducing imidates to produce an 8a-azalide...

C - Chemistry – Metallurgy – 07 – H

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C07H 17/08 (2006.01)

Patent

CA 2361043

A method for reducing imidate intermediates arising from Beckmann stereospecific rearrangement of a compound of general formula (II), characterized in that said intermediates are not isolated from the pyridine-based reaction medium and are directly reduced with the aid of a sufficient quantity of activated borohydride.

Procédé utile pour réduire les intermédiaires imidates issus du réarrangemernt stéréospécifique de Beckmann d'un composé de formule générale (II) caractérisé en ce que lesdits intermédiaires ne sont pas isolés dudit milieu réactionnel à base de pyridine et y sont directement réduits à l'aide d'une quantité suffisante en borohydrure activé.

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