A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/49 (2006.01) A61K 9/08 (2006.01) A61K 31/00 (2006.01) A61K 31/404 (2006.01) A61K 31/407 (2006.01) A61K 31/55 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2219280
Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having potassium channel blocking activity. Examples of potassium channel blockers utilized in the pharmaceutical composition and method of treatment are quinine, tremogenic indole alkaloids, such as Penitrem A and paspalicine, and insect toxins such i as charybdotoxin and iberiotoxin.
L'invention porte sur des compositions pharmaceutiques et sur une technique s'inscrivant dans le cadre du traitement du glaucome et/ou de l'hypertension oculaire dans l'oeil d'un mammifère. La technique consiste à introduire dans l'oeil du mammifère la composition pharmaceutique de l'invention contenant, comme ingrédient actif, un ou plusieurs composés présentant une activité de blocage du canal potassium. La quinine, des alcaloïdes indoliques générateurs de tremblement, comme Pénitrem A et la paspalicine, ainsi que des toxines d'insectes telles que la charybdotoxine et l'ibériotoxine, sont des exemples d'agents de blocage du canal potassium utilisés pour cette composition pharmaceutique et dans le cadre de la technique de traitement correspondante.
Adorante Joseph S.
Ruiz Guadalupe
Woldemussie Elizabeth
Allergan
Allergan Inc.
Gowling Lafleur Henderson Llp
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