Method for reducing pain

Details Method for reducing pain Method for reducing pain

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 31/195 (2006.01) A61K 31/4168 (2006.01) A61K 31/445 (2006.01) A61K 31/4468 (2006.01) A61K 31/4535 (2006.01) A61K 38/17 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2540895

The present invention is direct to a method of producing analgesia in a mammalian subject. The method includes administering to the subject an omega conopeptide, preferably ziconotide, in combination with an analgesic selected from the group consisting of morphine, bupivicaine, clonidine, hydromorphone, baclofen, fentanyil, buprenorphine, and sufentanil, or its pharmaceutically acceptable salts thereof, wherein the .omega.-conopeptide retains its potency and is physically and chemically compatible with the analgesic compound. A preferred route of administration is intrathecal administration, particularly continuous intrathecal infusion. The present invention is also directed to a pharmaceutical formulation comprising an omega conopeptide, preferably ziconotide, in combination with an analgesic selected from the group consisting of morphine, bupivicaine, clonidine, hydromorphone, baclofen, fentanyl, buprenorphine, and sufentanil.

La présente invention concerne une méthode de génération d'une analgésie chez un sujet mammalien. Cette méthode consiste à administrer au sujet un .omega.-conopeptide, de préférence, le ziconotide mélangé à un analgésique sélectionné parmi le groupe englobant la morphine, la bupivacaïne, la clonidine, l'hydromorphone, le baclofen, le fentanyil, la buprénorphine et le sufentanil, ou ses sels acceptables pharmaceutiquement, l'.omega.-conopeptide gardant sa puissance et étant physiquement et chimiquement compatible au composé analgésique. Une voie d'administration préférée est l'administration intrathécale, notamment, la perfusion intrathécale. Cette invention a aussi pour objet une préparation pharmaceutique contenant un .omega.-conopeptide, de préférence, le ziconotide mélangé à un analgésique sélectionné parmi le groupe englobant la morphine, la bupivacaïne, la clonidine, l'hydromorphone, le baclofen, le fentanyil, la buprénorphine et le sufentanil.? ¿

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