Method for reducing susceptibility to hiv infection

Details Method for reducing susceptibility to hiv infection Method for reducing susceptibility to hiv infection

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01)

Patent

CA 2313805

There is disclosed a method of reducing susceptibility of cells to infection by a retrovirus, comprising contacting the cells with an amount of a CD40 binding protein effective to reduce the expression of the chemokine receptor CCR5, and/or induce a post-entry block of the replication of the retrovirus. The method is useful in treating individuals infected with, or at risk of being infected with, HIV. CD40 binding proteins include CD40 ligand, monoclonal antibodies that specifically bind CD40, and combinations thereof. CD40 binding proteins may also be used in combination with other cytokines, including GM-CSF, IL-2 and IL-15.

L'invention concerne un procédé pour diminuer la sensibilité des cellules à l'infection par un rétrovirus. Le procédé consiste à mettre les cellules au contact d'une protéine de liaison au CD40 utilisée en quantité suffisante pour réduire l'expression du récepteur CCR5 de la chémokine, et/ou à inhiber la réplication du rétrovirus après son entrée. Ce procédé convient pour le traitement d'individus infectés ou risquant d'être infectés par le VIH. Les protéines de liaison au CD40 incluent le ligand CD40, des anticorps monoclonaux qui se lient spécifiquement au CD40, ou des combinaisons desdits éléments. Les protéines de liaison au CD40 peuvent également s'utiliser en association avec d'autres cytokines, y compris GM-CSF, IL-2 et IL-15.

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