C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2068593
A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.
Daugherty Bruce L.
Mark George E. III
Padlan Eduardo A.
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Padlan Eduardo A.
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