Method for reducing the viscosity of pathological mucoid...

Details Method for reducing the viscosity of pathological mucoid... Method for reducing the viscosity of pathological mucoid...

A - Human Necessities

61

K

A61K 38/17 (2006.01) G01N 33/68 (2006.01) A61K 31/725 (1995.01)

Patent

CA 2159205

The invention is generally directed to methods of promoting normal respiratory tract airflow in patients with restricted airflow and ciliary clearance caused by the presence of pathological airway contents, and particularly mucoid contents. Actin-binding proteins are administered into the respiratory tract of a patient with a pathological respiratory condition involving the presence of such contents. The actin-binding protein binds to actin polymers in the contents and decreases the viscosity. The actin-binding proteins also prevent actin from binding to exogenous or endogenous DNase 1, thus increasing the degradation of DNA polymers in the contents.

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