Method for reduction, stabilization and prevention of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/497 (2006.01) A61K 31/47 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2590224

There is to provide is an agent for reduction of a lipid rich plaque, stabilization of a lipid rich plaque and/or prevention of rupture of a lipid rich plaque in an atherosclerotic lesion comprising an effective amount of 2- [4-[2-(benzimidazole-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6- methyl-3-pyridyl]acetamide (hereinafter, referred to as compound 1), its pharmaceutically acceptable salt or a hydrate thereof and Pitavastatin, and a pharmaceutically acceptable carrier, wherein the agent is intended to be simultaneously administered, or separately administered with interval of time to a patient in need thereof. There is also to provide a method for reduction of a lipid rich plaque, stabilization of a lipid rich plaque and/or prevention of rupture of a lipid rich plaque in an atherosclerotic lesion, comprising simultaneously administering, or separately administering with interval of time an effective amount of the compound 1, its pharmaceutically acceptable salt or a hydrate thereof and an effective amount of Pitavastatin to a patient in need thereof.

L'invention a pour objet un agent pour la réduction d'une plaque riche en lipides, la stabilisation d'une plaque riche en lipides et/ou la prévention de la rupture d'une plaque riche en lipides dans une lésion athéroscléreuse comprenant une quantité efficace de 2-[4-[2-(benzimidazole-2-ylthio)éthyl]pipérazin-1-yl]-N-[2,4-bis(méthylthio)-6-méthyl-3-pyridyl]acétamide (ci-après appelé composé 1), de son sel acceptable du point de vue pharmaceutique ou d'un hydrate de ceux-ci et de Pitavastatine, et un véhicule acceptable du point de vue pharmaceutique, lequel agent est destiné à être administré à un patient qui en a besoin sous forme de ses composants administrés simultanément ou séparément à un certain intervalle de temps. L'invention concerne également un procédé pour la réduction d'une plaque riche en lipides, la stabilisation d'une plaque riche en lipides et/ou la prévention de la rupture d'une plaque riche en lipides dans une lésion athéroscléreuse, comprenant l'administration simultanée ou l'administration séparée à un certain intervalle de temps d'une quantité efficace du composé 1, de son sel acceptable du point de vue pharmaceutique ou d'un hydrate de ceux-ci, et d'une quantité efficace de Pitavastatine à un patient qui en a besoin.

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