Method for regulating metabolism with dopamine beta...

A - Human Necessities – 61 – K

Patent

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A61K 31/44 (2006.01) A61K 31/00 (2006.01) A61K 31/01 (2006.01) A61K 31/015 (2006.01) A61K 31/03 (2006.01) A61K 31/05 (2006.01) A61K 31/055 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/145 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01) A61K 31/325 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01)

Patent

CA 2219981

Disclosed herein are methods for regulating or ameliorating lipid and glucose metabolism and reducing in a vertebrate animal body fat stores, insulin resistance, hyperinsulinemia, hyperglycemia, hyperlipidemia, elevated blood lipoproteins (such as triglycerides and cholesterol including chylomicrons, VLDL and LDL) and/or increasing in the subject the plasma HDL. The methods comprise administration or timed administration of inhibitors or dopamine beta hydroxylase (DBH).

L'invention présente des procédés pour régulariser ou améliorer le métabolisme glucosique ou lipidique et réduire, chez un animal vertébré, les réserves de graisse, la résistance insulinique, l'hyperinsulinémie, l'hyperglycémie, l'hyperlipidémie, la présence élevée de lipoprotéines dans le sang (telles que les triglycérides et le cholestérol, y compris les chylomicrons, les VLDL (lipoprotéines de très basse densité) et les LDL (lipoprotéines de basse densité) et/ou augmenter dans le sujet les HDL (lipoprotéines de haute densité) du plasma. Ces procédés comprennent l'administration ou l'administration à un moment déterminé d'inhibiteurs de la dopamine bêta hydroxylase (DBH).

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