Method for removing n-terminal methionine

Details Method for removing n-terminal methionine Method for removing n-terminal methionine

C - Chemistry, Metallurgy

07

K

C07K 1/12 (2006.01) C07K 14/48 (2006.01) C07K 14/485 (2006.01) C07K 14/55 (2006.01) C07K 14/61 (2006.01) C07K 14/635 (2006.01)

Patent

CA 2207723

The present invention provides a method for chemically removing a N-terminal methionine residue selectively, specifically and efficiently from a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal. The method reacts a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal with an .alpha.-diketone derivative, followed by hydrolysis.

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